![]() We explored this question and more in our brand new edition. ![]() The nearest airport is Cozumel International Airport, 35.4 km from Terrazas Luxury Retreat. Throughout the year, Baja California and the Central Pacific Coast. Rather than being presented with a menu, they ask about your food preferences. Mexico City has undergone a huge revolution, now attracting visitors to rent private vacation homes where they can explore its wealth of cultural wonders. ![]() These sessions are led by yoga experts, sound healers and meditation guides. #5 Best Value of 155 Exclusive Resorts in Mexico. Get PC Daily delivered directly to your inbox don't miss anything! STAFF & SERVICES Deep Ellums Surfing Restaurant Takes Shape, Smoky Rose Expands, and an Austin-Based Cafe-Slash-Bike Shop Co A European-Style Cocktail Bar in West Village, a 90s Throwback Spot in Snider Plaza, and Another Bobs Ex Three New Downtown Dallas Restaurant Openings and One Surprising West Village Closure. Recommendations can lead you to savor a mouthwatering plate of authentic al pastor tacos. Surrounded by nature, you can unwind, be free and feel at home. BEDROOM & BATHROOM Stone floors are a polished backdrop in the great room, pottery adds a colorful accent, and theres plenty of seating on the sectional, around the dining table, and at the breakfast bar in the gourmet kitchen. Your Casa Bella holiday begins with transportation to the villa, a meet-and-greet with your personal concierge, and complimentary chips, salsa, guacamole and beverages on arrival. Do ancient civilizations fascinate you? 2023 Hearst Magazine Media, Inc. With a relaxing escape topping every traveler's wishlist, we curated a list of Mexico's best wellness retreats. Credit: 2021 Rancho La Puerta For those seeking a vacation that emphasizes healthful activities, Mexico is an ideal spot. Whether you are hosting a corporate meeting, planning a product launch or looking for a great option for a company reward trip, Journey Mexico specializes in providing clients with unique and creative options. Theres also a barbecue and firepit and, for other evening entertainment, satellite Television and surround sound. There may or may not have been a period of listening to Olivia Rodrigo on repeat. Distance in property description is calculated using OpenStreetMap, 160 m So pack your A-game and head for the tee at one of Mexicos incredible greens! Below are some of the wellness essentials I packed on my trip to Paradisus Los Cabos. ![]() This trip is an off-the-beaten-path adventure that visits the Sea of Cortez coastline in Baja California. And a Riviera Maya vacation is every persons fantasy, where luxury villa rentals are wedged between spectacular snorkeling sites, upscale spas and resorts, and treasured Mayan Ruins. Tabitha Johnson, a nationally-renowned couples and relationship expert. COUPLES RETREAT SCHEDULE + ACTIVITIES During the retreat, you'll attend a small, intimate group session in the morning, lead by Dr. Perched cliffside overlooking Bahia de Banderas, its easy to get distracted from your primary objective dining by the blissful view. When youre ready to head out, you will find amazing options for golf, watersports and sightseeing nearby. Clear blue waters and plenty of beach bars are a good start, and for those who like to get active on the sand, theres beach volleyball, jet skiing, and kayaking. Luxury rehabs offer peaceful settings with experienced psychiatrists and staff to improve clients' well-being. Publishers of: Express Travel Group to join Helloworld stable, Travel Associates unveils unique one-of-a-kind Experiences, Virgin Galactic plans monthly commercial flights from August 2023. I suffer from Melasma and take sun protection seriously. Luxury Retreats Mexico May 1 - 31 Clear All Luxury Retreats in Mexico in May 2023 Showing 1 to 17 of 17 results Recommended first Free Gift 5 Day Self Discovery & Mayan Ceremony Retreat, Mexico Riviera Maya, Quintana Roo, Mexico Available all year round A holiday at the Bergwiesenglck boutique hotel and chalet doesnt just have a lasting impact on the heart and soul nature also has reason to be grateful for the efforts of the two hotel owners Anna and Rudolf Schuchter when it comes to protecting the environment. Click below and we will send you an email with a link to confirm your registration and your constent to receiving our newsletter. The right home for your next dream getaway.
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![]() It is completely within reason to own 24 glasses or more if you entertain even occasionally. Some people just decide to buy a large number of one style of white glasses. The fuller wines belong in bigger glasses, because the stronger aromas collect in the glass and let you enjoy a powerful taste experience when drinking.These glasses are made for floral aromas and let the wine's acidity stand out. For lighter wines, select the glass with the smaller bowl.Many experts make a clear distinction between a glass for a light-bodied white wine, like a Riesling, and a glass for a full-bodied white wine, like Chardonnay. In others, it's only just visible, but still spills the wine into your mouth as it was meant to.įor white wine glasses, you may have an easier time shopping. Burgundy glasses have a slight curve at the lip or opening of the glass.This is another good one to stock at home. It looks a little like an oversized white wine glass. The Bordeaux glass is the tallest of the red glasses.Fill them like you would any other glass-just over the widest part of the bowl. These wine glasses are extra wide, so they're easy to spot. A great first specialty glass to choose is the Pinot Noir glass.They have wider mouths and fuller bowls to allow the deeper aromas and tastes of red wine to become prominent at each minute stage of enjoyment, from inhaling to swallowing (or spitting, in some cases). Red wine glasses are generally bigger than their white wine counterparts. Let your guests share in the pleasure of a well-paired meal and bottle served in the perfect glass. If you love to entertain, it's even more crucial to round out your set of glasses. That way, your next tasting can impart the exact notes of your favorite wines without missing a flavor. Take a look at your collection of wine glasses today and see where you can fill in the gaps. Any wine aficionado knows wine is delicious in any glass, but becomes superlative and reaches its full potential in the right glass. Beyond the colour and its incredibly pigmented payoff, the texture is flexible and moisturising on the lips, making it such a delight to wear often. This lip combo is perfect for any event, whether it's a wedding or brunch. With a little bit of brown lip liner, Pillow Talk Medium seamlessly blended into my complexion, delivering that effortless soft-glam look. The berry tones of this lipstick make it approachable for those with a tan skin tone like myself, and it has both warm and cool elements that make it suitable for a variety of undertones. My skin tone is tan/dark tan with neutral undertones, and I always had a tough time finding nudes that suited my complexion, especially a rosy nude that looks romantic and flirty. "As someone who thought only deep reds, burgundy, and berry tones looked good on me, Charlotte Tilbury's Pillow Talk Medium was my first official foray into the pink-nude realm, and I never looked back. Keep reading to see what we think.Ĭharlotte Tilbury Matte Revolution Lipstick in Pillow Talk Medium (£27) We even included a few tips and tricks we used to make the Pillow Talk shades suitable for our skin tones and undertones. Some of us opted to try out the original colour, while others wanted to give Pillow Talk Medium a whirl. To truly see if the Pillow Talk shades are universally flattering, we tested out the wear, formulation, and look of the iconic Pillow Talk lipstick shades on six different skin tones. Enter Pillow Talk Medium, the warm berry-pink alternative that delivers that romantic, nude-pink effect on those with tan and dark skin tones. However, those with dark skin tones noticed they were not getting that same rosy nude, "my lips but better" look. In fact, Charlotte Tilbury created a whole collection dedicated to this romantic, soft-glam shade.Ĭharlotte Tilbury's Pillow Talk is supposed to be universally flattering. It's gone viral on social media plenty of times throughout the years, and the brand even claims that one Matte Revolution Pillow Talk lipstick is sold every two minutes. After the shade gained popularity, the brand made a lipstick version of it as part of its Matte Revolution line in 2017, and the rest is history. It first hit the scene in 2013 as a Lip Cheat lip liner shade that left the impression of being a universally flattering pink tone. Whether it's paired with a bold smoky eye, graphic liner, or a barely there, minimal look, this lipstick shade proves to be a versatile staple, day and night. Pillow Talk delivers a natural-hued pink lip that's timeless and elegant. Only a select few formulas and shades have surpassed trends and become iconic in their own right - and one such shade is Charlotte Tilbury's Pillow Talk.įrom celebrities to brides, people have been praising this gorgeous nude-pink colour for years. And with the near-endless amount of options to choose from, it's no surprise we're always on the hunt for the next best lipsticks. ![]() If you buy a product we have recommended, we may receive affiliate commission, which in turn supports our work.įrom a bold red lip to an ideal nude, the right lipstick can pull a look together like no other. As POPSUGAR editors, we independently select and write about stuff we love and think you'll like too. ![]() ![]() “We have a couple of other cuts that we feel very strongly about,” he added. “We ended up making 12 to 14 songs,” Littlemore admitted. Speaking with TMN in 2021, Nick Littlemore admitted “Cold Heart” is just one of many nuggets that emerged from their studio sessions. There’s more where “Cold Heart” came from. PNAU, then a duo of Nick Littlemore and Mayes, worked with Elton John on the 2012 remix album Good Morning To The Night, which went to No. 1 in Australia, at 10 non-consecutive weeks. When it got there, it made Elton, at 74 years, seven months and 14 days, the oldest artist to top the ARIA Singles Chart, overtaking Paul McCartney. In Australia, the single took 12 weeks to reach the summit. 1 single in his homeland and first for 16 years, making the pop legend the first act in history to score a U.K. The single was nominated for song of the year at the Brit Awards, collected a Billboard Award for Top Dance/Electronic Song, it has cruised past one billion streams, and saw the trio crack Spotify’s Top 100 streamed artists.Īlong the way, the single, which interpolates “Sacrifice” with “Rocket Man,” “Kiss the Bride” and “Where’s My Shoorah,” smashed several records. “Cold Heart” has been a global smash since its release in 2021. Also nominated was Sydney singer and rapper The Kid LAROI for “Stay,” his collab with Justin Bieber, while “We Don’t Talk About Bruno ” Future featuring Drake & Tems’ “Wait For U’” and Lil Nas X featuring Jack Harlow’s “Industry Baby” made the “best collaboration” shortlist.ĬONGRATS to & for taking home the #AMAs Collaboration of the Year for "Cold Heart – PNAU Remix)! □□ /7mOmwIQQ50- American Music Awards November 20, 2022 Any questions, please let me know in advance of buying. This could be due to poor feedback, having private feedback which I'm not allowed to examine, or other factors. ![]() Virgin Islands, Uganda, Ukraine, United Arab Emirates, United Kingdom, United States, United States Minor Outlying Islands, Uruguay, Uzbekistan, Vanuatu, Vatican City, Venezuela, Viet Nam, Wallis and Futuna, Western Sahara, Yemen, Zambia, Zimbabwe I have the right to refuse to sell, so if someone has bought a game I may cancel and refund the game at my discretion. Afghanistan, Åland Islands, Albania, Algeria, American Samoa, Andorra, Angola, Anguilla, Antarctica, Antigua and Barbuda, Armenia, Aruba, Australia, Austria, Azerbaijan, Bahamas, Bahrain, Bangladesh, Barbados, Belarus, Belgium, Belize, Benin, Bermuda, Bhutan, Bolivia, Bonaire, Saint Eustatius and Saba, Bosnia and Herzegovina, Botswana, Bouvet Island, Brazil, British Indian Ocean Territory, British Virgin Islands, Brunei, Bulgaria, Burkina Faso, Burundi, Cambodia, Cameroon, Canada, Cape Verde, Cayman Islands, Central African Republic, Chad, Chile, China, Christmas Island, Cocos (Keeling) Islands, Colombia, Comoros, Congo, Cook Islands, Costa Rica, Côte d'Ivoire, Croatia, Cuba, Curaçao, Cyprus, Czech Republic, Democratic Republic of Congo, Denmark, Djibouti, Dominica, Dominican Republic, East Timor, Ecuador, Egypt, El Salvador, Equatorial Guinea, Eritrea, Estonia, Ethiopia, Falkland Islands, Faroe Islands, Federated States of Micronesia, Fiji, Finland, France, French Guiana, French Polynesia, French Southern Territories, Gabon, Gambia, Georgia, Germany, Ghana, Gibraltar, Greece, Greenland, Grenada, Guadeloupe, Guam, Guatemala, Guernsey, Guinea, Guinea-Bissau, Guyana, Haiti, Heard Island and Mcdonald Islands, Honduras, Hong Kong (SAR of China), Hungary, Iceland, India, Indonesia, Iran, Iraq, Ireland, Isle of Man, Israel, Italy, Jamaica, Japan, Jersey, Jordan, Kazakhstan, Kenya, Kiribati, Kosovo, Kuwait, Kyrgyzstan, Laos, Latvia, Lebanon, Lesotho, Liberia, Libya, Liechtenstein, Lithuania, Luxembourg, Macao (SAR of China), Macedonia, Madagascar, Malawi, Malaysia, Maldives, Mali, Malta, Marshall Islands, Martinique, Mauritania, Mauritius, Mayotte, Mexico, Moldova, Monaco, Mongolia, Montenegro, Montserrat, Morocco, Mozambique, Myanmar, Namibia, Nauru, Nepal, Netherlands, Netherlands Antilles, New Caledonia, New Zealand, Nicaragua, Niger, Nigeria, Niue, Norfolk Island, North Korea, Northern Mariana Islands, Norway, Oman, Pakistan, Palau, Palestinian Territories, Panama, Papua New Guinea, Paraguay, Peru, Philippines, Pitcairn, Poland, Portugal, Puerto Rico, Qatar, Réunion, Romania, Russia, Rwanda, Saint Barthélemy, Saint Helena, Saint Kitts and Nevis, Saint Lucia, Saint Martin, Saint Pierre and Miquelon, Saint Vincent and the Grenadines, Samoa, San Marino, Sao Tome and Principe, Saudi Arabia, Senegal, Serbia, Seychelles, Sierra Leone, Singapore, Sint Maarten, Slovakia, Slovenia, Solomon Islands, Somalia, South Africa, South Georgia and South Sandwich Islands, South Korea, Spain, Sri Lanka, Sudan, Suriname, Svalbard and Jan Mayen, Swaziland, Sweden, Switzerland, Syria, Taiwan (Region of China), Tajikistan, Tanzania, Thailand, Togo, Tokelau, Tonga, Trinidad and Tobago, Tunisia, Turkmenistan, Turks and Caicos Islands, Tuvalu, U.S. This key can only be activated in the following regions. I cannot be held responsible for any software issues such as a game crashing/lagging. Please make sure you check the system requirements of the game on Steam to see if the game is playable on your hardware. Item will normally be sent to you quite quickly, normally within minutes, however please allow up to 24 hours during peak hours time. 3 Steam keys will be emailed to you, so no physical item will be sent/received. ![]() ![]() ![]() Dare to enter the varied Zones as you cross the Arid Desert, trek through the dense Rainy Foliage, freeze your nuts off in the Nuclear Winter, and roam under the Ashen Skies. Fight back with a devastating arsenal as you make your way through a violence-stricken town. The only choice is clear: Get them before they get you. Item: 195700521064 DLC Postal Redux & 2 & Paradise Lost (chiavi PC Steam) prezzo di acquisto £20,98. ![]() GIFs, one of the most fashionable GIF makers on Android apps, is helpful for people to express their feelings and record their unforgettable moments. You may also like: Solved – How to Add Text to GIF 7. In addition to making GIFs, it is also a perfect GIF editor like adding stickers, text, and frames to the GIF. Its features include converting images and video to GIF, decoding and encoding GIF, and saving GIFs on your phone. GIF Pro is a powerful and easy GIF maker on Android apps to make animated GIFs. You may also like: How to Reverse GIF – 4 Solutions 6. Of course, it can export GIF images with high-quality resolution, and it can fast crop, rotate, and flip GIF images. GIF Maker offers 30+ filters to bring GIF images more effects. And it also supports screen recorder to GIF, images to GIF, video to GIF, and it can reverse GIF. GIF Maker, one of the easiest GIF makers on Android apps, supports video to GIF, which is the most prominent feature of GIF Maker. Besides, it supports texting GIFs to your friends and sharing your GIF on Facebook, Twitter, Instagram, and so on. It is a good GIF camera that is available to record personalized GIF and to add interesting stickers. GIPHY is a superb GIF maker on Android apps, supplying free GIFs, stickers, and memes. Also, this GIF maker is a fantastic video trimmer. Except for making GIFs, it also offers other functions, such as adding captions to GIF or videos and adjusting text color and size. Video &GIF Memes is one of the most popular GIF makers on Android apps. You may also like: The Best Way to Convert Video to GIF (Windows, iPhone/Android). What’s more, it can play videos in positive and negative order, and it’s a nice video speed controller. One notable feature is that this app is endowed with adding captions, supporting various caption styles, and providing enormous color options and typeface. Gif Guru is also a versatile GIF maker on Android apps and it supports image to GIF and video to GIF. Even though you don’t have any experience at all, you can make GIFs with your images because of its easy operation. One prominent feature is that this GIF maker has copious and adjustable color palettes. PicsArt Animator, one of the best GIF makers on Android apps, has powerful editing functions. Let’s glance over the post quickly and find a GIF maker you like. If you want to make GIFs on your smartphone, a GIF maker is essential. If you are interested in video editing, you can try MiniTool MovieMaker developed by MiniTool. ![]() Therefore, more and more people fall in love with making GIFs on their smartphones because of its convenience. GIF always appears on social media because it is often used to express people’s feelings and emotions and it is really interesting and funny. Have any Questions? Comments? Issues? Visit Giphy.Nowadays, video editing and GIF editing are very prevalent among the public. Find a GIF or sticker you love? Double tap it to save to your favorites for easy access later. ![]()
Social media contest templatesĬontests on social media are ideal ways to drive engagement, followers, leads, and brand awareness. This calculator lets you measure engagement on a post-by-post basis or for an entire campaign for any social network. Engagement rate calculatorĮngagement rate is the best way to tell if your audience cares about what you’re posting on social media and what they want to see more of. This customizable social media policy template covers all the basics to make it quick and easy to establish how your organization is represented online. It is vital for maintaining your brand voice and reducing social media risks.ĭownload your social media policy templateįill in the blanks and easily set the guidelines for your brand on social media. This official company document must provide guidelines for your organization’s social media use. Social media policy templateĪll organizations need a social media policy. To use it in Google Docs, click the “File” tab and then select “Make a copy…” from the dropdown menu. Get the free social media style guide template Make sure your social media style guide doesn’t miss any important sections by using our free template. Social media style guide templateĪ style guide for social media ensures all the team members who talk and write about your brand do so in a consistent way that supports your brand image and goals. This template will guide you through a full social network analysis of your competition and help you identify your strengths, weaknesses, opportunities and threats. Get the free competitive analysis template It’s an easy way to get useful insights into your own business and your online audience. Competitive analysis templateĬonducting a competitive analysis for social media will help you identify gaps in your own strategy and stay one step ahead of your competition. Use this important social media template to conduct customer research and better target your audience by creating personas for your ideal customer(s). To use it in Google Docs, click the “File” tab and then select “Make a copy…” from the dropdown menu.īonus: Our guide to conducting a social media audit will walk you through each step of the process. Gathering these insights will help you get the most out of your social marketing budget and resources. It’s also handy for identifying impostor accounts, out-of-date profiles, and new opportunities to engage your audience. This social media template template will show what is and isn’t working on social media-and what to do next. Also use it to track results and present the plan to your boss, teammates, and clients. ![]() ![]() Bonus: Get a free social media strategy template to quickly and easily plan your own strategy. ![]() JERKY! Look at all those kinds of jerky! Protein Bars It is also available at grocery stores, but I think buying it at a gas station is part of the road trip experience. Beef jerky has a strong odor, and some people (like me) who get motion sickness can find the smell triggering.īeef jerky is also a great option if you plan on getting your snacks when you do a rest stop as most gas stations sell it. One thing to think about with this snack though is the smell. From long sticks of beef jerky, to diced-up pieces, you can find an option that works for you. This dried meat snack can be found in various sizes and flavors. I think when most people think of a protein snack on road trips, beef jerky comes to mind. Here are the best protein snacks according to the sources I mentioned above. I won’t label any of the sections “healthy road trip snacks” because people’s idea of healthy foods is always different, but I will break them down by things like protein, fresh produce, salty snacks, etc Best Road Trip Snacks – Protein Options I think one of the best ways to break down this list is by the type of snacks. It doesn't matter how old you get, buying snacks for a road trip should always look like an unsupervised 9-year-old was given $100.- bananafanafofisa June 9, 2016 2023’s Best Road Trip SnacksĮnought of the tips, right? You are just here to find some good road trip snacks.īelow we will cover some of the best road trip snacks based on a little bit of my research, polls I have done with my readers and social media followers, and my personal opinions. In this case, I think it is best to only pack what you know will be eaten before these checkpoints, and then purchase more in state. Just be aware that you may be required to fork over things like bananas, apples, grapes, oranges, carrots, etc. While sometimes you will be waved through, other times they may be limiting certain produce products due to disease, etc that they are trying to keep away from their own crops. The biggest example of this is that California has agricultural checkpoints as you enter the state. This may seem silly, but depending on where you are heading (looking at you California) you may not be allowed to bring some of your snacks in. Either way, snacks are a must have for a long road trip. How you plan to utilize snacks will play a big part in which snacks you choose. In that case, you may want to pack sandwich fixings, protein bars, and maybe some string cheese. Others, they may want to pack items that will make it so they don’t have to stop for meals at restaurants. Road trip snacks can be just extra fun to snack on, but some families may want to use road trip snacks as part of their meal planning.Īn example might be that you know during your road trip, you will most likely stop at fast food places for meals, so you want to make sure you have some healthy snacks like fresh fruit or vegetables available. Heading on a quick road trip! Have our snacks ready! How Will Snacks Play Into Your Meal Planning ![]() In my family we personally buy some snacks we will take with us at the grocery store, and then now and then, when we stop at a convenience store, we will let the kids pick out a treat or snack. It also doesn’t have to be one or the other. There is no right or wrong way to purchase your snacks, but you will want to think about what makes it easier for you. Are you going to buy all of your snacks beforehand at your local grocery store? Will you only buy snacks when you stop at a gas station? This seems silly to spend time thinking about, but you should. You don’t want to just go out and buy everything on our list, and you also don’t want to take something that you end up having to throw out for some reason (we will cover those reasons in a bit).īelow are some things you should consider before stocking up on road trip snacks for your next vacation. When planning snacks for a road trip, it is important to take a few things into consideration.
![]() Rearrange document tabs with drag and drop.Drag the document tabs onto the screen to “remove” them into a separate window, or drag them to the tab bar to convert them back to the document tab.Open documents in tabs or in separate windows – just like in a web browser.Touch screen mode with larger icons and more spacing.Switch to “dark mode” to reduce eye strain.“Quick Access Toolbar” for commonly used commands.Create and edit text files using TextMaker.Edit and manage documents, spreadsheets, and presentations.Dozens of new drop-down controls with options panels, making document creation much easier (available with the ribbon as well as in classic mode).You can use SoftMaker Office with modern ribbons or with classic menus and toolbars. Can be installed to USB flash drive so it can be used on any PC without installation.Version manager keeps a freely selectable number of versions of each file and allows you to revert to any previous version.Delete file history with just one click.SoftMaker Office now uses the original Microsoft Office DOCX, XLSX and PPTX formats, eliminating the need to convert documents for colleagues or business partners.Features of SoftMaker Office Professional 2021 This allows you to edit your documents in Microsoft Office directly and without converting. In conclusion, SoftMaker Office Professiona is a complete suite of office applications with many powerful features and options.Įliminate annoying import and export: SoftMaker Office uses Microsoft’s DOCX, XLSX, and PPTX formats as the default file formats. All commands and functions are easily accessible to provide a complete environment to handle all operations. BasicMaker is there to provide all the functionality needed for macro development and testing purposes. There are various bundled components that come with a dedicated toolkit and macro script for automation purposes. It enhances productivity and handles all documents including text documents, presentations, spreadsheets and other documents. This great office suite is one of the best alternatives to Microsoft Office. ![]() It is a very easy to use application with simple UI and self explanatory options. SoftMaker Office Professional provides a complete environment for editing, managing and sharing documents easily. SoftMaker Office Professional 2021 is a powerful application for creating, editing, and managing spreadsheets, documents, and presentations. How to install SoftMaker Office Professional 2021.SoftMaker Office Professional 2021 Free Download.System requirements of SoftMaker Office Professional 2021.Features of SoftMaker Office Professional 2021. ![]() Regarding safety, the safety profile of combination treatment with pembrolizumab plus lenvatinib was found to be consistent with previously reported studies. Patients were randomized 1:1 to receive either pembrolizumab at a dose of 200 mg intravenously (IV) every 3 weeks for up to 35 cycles (approximately 2 years) in combination with lenvatinib at a dose of 20 mg orally once daily, or chemotherapy with physician’s choice of either doxorubicin at a 60 mg/m2 dose by IV every 3 weeks for up to a maximum cumulative dose of 500 mg/m2 or paclitaxel at a 80 mg/m2 dose by IV on a 28-day cycle (3 weeks of receiving weekly paclitaxel and 1 week of not receiving paclitaxel).Īccording to an analysis conducted by an independent data monitoring committee, pembrolizumab plus lenvatinib demonstrated a statistically significant and clinically meaningful improvement in OS, PFS, and ORR versus chemotherapy (treatment of physician’s choice of doxorubicin or paclitaxel). Key secondary end points include ORR by BICR per RECIST v1.1 and safety/tolerability. The study’s dual primary end points are OS and PFS, as assessed by Blinded Independent Central Review (BICR) per Response Evaluation Criteria in Solid Tumors Version (RECIST) v1.1. The total study cohort consisted of 697 patients with tumors that were non-MSI-H or pMMR, and 130 patients with tumors that were MSI-H or dMMR. ![]() The multicenter, randomized, open-label, phase 3 trial enrolled a total of 827 patients. Most importantly, we are grateful for the trust that the patients and healthcare professionals who participated in this trial have shown us.” “We are encouraged by the data observed in KEYNOTE-775/Study 309, which represent a possible step forward for patients impacted by advanced endometrial carcinoma and support the results seen in the advanced endometrial cancer cohort of KEYNOTE-146/Study 111,” Takashi Owa, vice president, chief medicine creation officer, and chief discovery officer of the Oncology Business Group at Eisai, said in a press release “As more clinical data from the LEAP (LEnvatinib And Pembrolizumab) program are revealed, we cannot help but be energized by the trajectory of our collaboration with Merck and the benefits we hope to provide to patients together. Importantly, these positive results were reported in the mismatch repair proficient (pMMR) subgroup and the intent-to-treat (ITT) study population, which includes patients with endometrial carcinoma that is pMMR and patients whose disease is microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR). The pivotal phase 3 KEYNOTE-775/Study 309 trial (NCT03517449), designed to evaluate the investigational use of pembrolizumab (Keytruda) plus lenvatinib (Lenvima), met its dual primary end points of overall survival (OS) and progression-free survival (PFS), as well as its key secondary end point of objective response rate (ORR) in patients with advanced endometrial cancer following at least 1 prior platinum-based regimen, according to Merck and Eisai, the developers of the agents. |
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